Effect of gastrin heptadecapeptide (G17) on oesophageal contractions in patients with diffuse oesophageal spasm.

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Effect of gastrin heptadecapeptide (G17) on oesophageal contractions in patients with diffuse oesophageal spasm.

An intravenous bolus of pentagastrin significantly increased the amplitude and duration of oesophageal body contractions in seven patients with diffuse oesophageal spasm (DES) when compared with five normal subjects (P greater than 0.05). In order to determine whether this stimulation also occurred at physiological gastrin concentrations, the effect of an intravenous infusion of gastrin heptade...

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Effect of gastrin heptadecapeptide ( G 17 ) on cesophageal contractions in patients with diffuse cesophageal spasm

An intravenous bolus of pentagastrin significantly increased the amplitude and duration of cesophageal body contractions in seven patients with diffuse cesophageal spasm (DES) when compared with five normal subjects (p > 0-05). In order to determine whether this stimulation also occurred at physiological gastrin concentrations, the effect of an intravenous infusion of gastrin heptadecapeptide (...

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Achalasia and diffuse oesophageal spasm in siblings.

We report the occurrence of achalasia and diffuse oesophageal spasm in brother and sister. The familial occurrence of these unusual disorders is consistent with the possibility that they share a common aetiology and indicates the potential importance of genetic predisposition.

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Oesophageal Spasm

Osgood (1889) is generally credited with the introduction of the term " diffuse spasm " of the oesophagus. However, though Moersch and Camp (1934) recorded a classical description of the clinical and radiological features of the disease it attracted little interest until the introduction of oesophageal motility studies in the 1950s. Since then a characteristic motility pattern has been describe...

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Anomalies of peristalsis in idiopathic diffuse oesophageal spasm.

Oesophageal manometry revealed 'interrupted peristalsis'--proximal sequential contraction with simultaneous pressure increases in the mid-oesophagus and sequential contraction distally--and abnormally slow distal propagation of peristalsis in seven of a consecutive series of 12 patients with idiopathic diffuse oesophageal spasm (IDOS). These two abnormalities occurred together in six patients. ...

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ژورنال

عنوان ژورنال: Gut

سال: 1979

ISSN: 0017-5749

DOI: 10.1136/gut.20.9.756